Intrarenal aneurysms in the tuberous sclerosis complex

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Intrarenal aneurysms in the tuberous sclerosis complex

The tuberous sclerosis complex (TSC, OMIM 191100) is a rare autosomal dominant syndrome of high penetrance characterized by hamartoma in multiple organs, namely brain, kidneys, heart, skin, eyes and lungs [1]. The classic clinical triad includes seizures, mental retardation and cutaneous adenoma sebacea. Besides common vascular abnormalities observed in angiomyolipoma, TSC can be associated wit...

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Intrarenal arterial aneurysms with haematuria in a patient with tuberous sclerosis complex.

Tuberous sclerosis complex (TSC) is an autosomal dominant disease with a wide spectrum of pathological lesions [1,2]. Almost half of the patients with TSC have an underlying renal pathology, mainly angiomyolipomas, cysts and/or renal cell carcinoma [3,4]. TSC rarely involves medium size and large vessels, including the renal arteries. Arterial aneurysms have been reported for intracranial arter...

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The tuberous sclerosis complex.

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that results from mutations in the TSC1 or TSC2 genes and is associated with hamartoma formation in multiple organ systems. The neurological manifestations of TSC are particularly challenging and include infantile spasms, intractable epilepsy, cognitive disabilities, and autism. Progress over the past 15 years has demonstrated t...

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Tuberous sclerosis complex.

Contrast enhanced computed tomography revealed a large well-circumscribed heterogenous retroperitoneal mass measuring 25 × 20 cm arising from the left kidney with predominant fat attenuation. Multiple smaller lesions were seen in the opposite kidney. Features were suggestive of diffuse angiomyolipomatosis of the kidneys. Hypodense lesions were also seen involving the lungslymphangioleiomyomatos...

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Tuberous Sclerosis Complex in Autism

OBJECTIVE To study the prevalence rate of tuberous sclerosis complex in autistic disorder. METHODS We studied one cohort of children followed up since 2005 until 2009, with autistic disorder, to determine the incidence of tuberous sclerosis complex. We established an autistic disorder registry in 2005 at China Rehabilitation Research Center. During the 4-year period (2005-2009), we collected ...

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ژورنال

عنوان ژورنال: Clinical Kidney Journal

سال: 2008

ISSN: 2048-8505,2048-8513

DOI: 10.1093/ndtplus/sfn151